Article
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.
Nature communications - 23 Jun 2021
Dunker Christine, Polke Melanie, Schulze-Richter Bianca, Schubert Katja, Rudolphi Sven, Gressler A Elisabeth, Pawlik Tony, Prada Salcedo Juan P, Niemiec M Joanna, Slesiona-Künzel Silvia, Swidergall Marc, Martin Ronny, Dandekar Thomas, Jacobsen Ilse D
Abstract excerpt
The ability of the fungal pathogen Candida albicans to undergo a yeast-to-hypha transition is believed to be a key virulence factor, as filaments mediate tissue damage. Here, we show that virulence is not necessarily reduced in filament-deficient strains, and the results depend on the infection model used. We generate a filament-deficient strain by deletion or repression of EED1 (known to be required for...
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