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Article

External validation of integrated genetic-epigenetic biomarkers for predicting incident coronary heart disease.

Epigenomics - 1 Jul 2021

Dogan Meeshanthini V, Knight Stacey, Dogan Timur K, Knowlton Kirk U, Philibert Robert

Abstract excerpt

Aim: The Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) Pooled Cohort Equation (PCE) for predicting risk for incident coronary heart disease (CHD) work poorly. To improve risk stratification for CHD, we developed a novel integrated genetic-epigenetic tool. Materials & methods: Using machine learning techniques and datasets from the Framingham Heart Study (FHS) and Intermountain...

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Identifiers

PMID: 34148365
DOI: 10.2217/epi-2021-0123
PMCID: PMC8356680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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