Article
The role of sirtuin 1 on the induction of trained immunity.
Cellular immunology - 1 Aug 2021
Mourits Vera P, Helder Leonie S, Matzaraki Vasiliki, Koeken Valerie A C M, Groh Laszlo, de Bree L Charlotte J, Moorlag Simone J C F M, van der Heijden Charlotte D C C, Keating Samuel T, van Puffelen Jelmer H, Jaeger Martin, Joosten Leo A B, Netea Mihai G
Abstract excerpt
Sirtuin 1 (SIRT1) has been described to modify immune responses by modulation of gene transcription. As transcriptional reprogramming is the molecular substrate of trained immunity, a de facto innate immune memory, we investigated the role of SIRT1 in the induction of trained immunity. We identified various SIRT1 genetic single nucleotide polymorphisms affecting innate and adaptive cytokine production of human...
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