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Article

Exocrine pancreas proteases regulate β-cell proliferation in zebrafish ciliopathy models and in murine systems.

Biology open - 15 Jun 2021

Hostelley Timothy L, Nesmith Jessica E, Larkin Emily, Jones Amanda, Boyes Daniel, Leitch Carmen C, Fontaine Magali, Zaghloul Norann A

Abstract excerpt

Pancreatic β-cells are a critical cell type in the pathology of diabetes. Models of genetic syndromes featuring diabetes can provide novel mechanistic insights into regulation of β-cells in the context of disease. We previously examined β-cell mass in models of two ciliopathies, Alström Syndrome (AS) and Bardet-Biedl Syndrome (BBS), which are similar in the presence of metabolic phenotypes, including obesity, but...

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Identifiers

PMID: 34125181
DOI: 10.1242/bio.046839
PMCID: PMC8249909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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