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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

26 May 2021

Abstract excerpt

Clonal hematopoiesis is a prevalent age-associated condition that results from the accumulation of somatic mutations in hematopoietic stem and progenitor cells (HSPCs). Mutations in driver genes, that confer cellular fitness, can lead to the development of expanding HSPC clones that increasingly give rise to progeny leukocytes harboring the somatic mutation. Because clonal hematopoiesis has been associated with...

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PMID: 34125083
DOI: 10.3791/61875

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