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Lentiviral Vectors Targeted to MHC II Are Effective in Immunization

19 Jan 2010

Abstract excerpt

Viral vectors for vaccination can be optimized by targeting vector entry to antigen-presenting cells (APCs). Here we describe lentiviral vectors (LVs) that are targeted to APC using a chimeric measles virus (MV) hemagglutinin (H). The MV H protein is mutated to prevent binding to MV receptors and incorporates a single-chain antibody that recognizes murine major histocompatibility complex class II (MHC II). This...

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PMID: 21247346
DOI: 10.1089/hum.2010.184

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