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Article

Constraining PERMANOVA and LDM to within-set comparisons by projection improves the efficiency of analyses of matched sets of microbiome data.

Microbiome - 9 Jun 2021

Zhu Zhengyi, Satten Glen A, Mitchell Caroline, Hu Yi-Juan

Abstract excerpt

BACKGROUND: Matched-set data arise frequently in microbiome studies. For example, we may collect pre- and post-treatment samples from a set of individuals, or use important confounding variables to match data from case participants to one or more control participants. Thus, there is a need for statistical methods for data comprised of matched sets, to test hypotheses against traits of interest (e.g., clinical...

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Identifiers

PMID: 34108046
DOI: 10.1186/s40168-021-01034-9
PMCID: PMC8191060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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