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A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

7 Jun 2021

Abstract excerpt

Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilizer of hypoxia-inducible factor-1α (HIF-1α). In vitro biophysical and cellular analyses demonstrate that this compound binds to Von Hippel-Lindau (VHL) and inhibits the VHL-HIF-1α interaction. Furthermore,...

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PMID: 34099651
DOI: 10.1038/s41467-021-23448-7

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