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Establishment of an induced pluripotent stem cell line from a patient with primary ciliary dyskinesia carrying biallelic mutations in CCNO.

Stem cell research - 1 May 2021

Xu Xuan, Dong Liu, Ma Cong, Xu Xiaofeng, Wu Huan, Wang Jianye, Zhou Ping, Cao Yunxia, Wei Zhaolian

Abstract excerpt

Primary ciliary dyskinesia (PCD) is an autosomal recessive hereditary disorder affecting motile cilia structure and function, which leads to respiratory diseases and infertility. Here, an induced pluripotent stem cell (iPSC) line of PCD was generated from peripheral blood mononuclear cells of a female patient carrying biallelic mutations in Cyclin O (CCNO) gene. Reprogramming was performed with the non-integrated...

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Identifiers

PMID: 34088001
DOI: 10.1016/j.scr.2021.102372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Establishment of an induced pluripotent stem cell line from a patient with primary ciliary dyskinesia carrying biallelic mutations in CCNO.PMID 34088001Read ↗

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