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Article

Generation of a human induced pluripotent stem cell line PUMCHi019-A from a dominant optic atrophy patient with an OPA1 mutation.

Stem cell research - 1 Apr 2022

Sun Zixi, Wu Shijing, Zhu Tian, Wei Xing, Han Xiaoxu, Zou Xuan, Sui Ruifang

Abstract excerpt

Dominant optic atrophy (DOA) is one of the most common type of hereditary optic atrophy. Here, we describe the generation and characterization of a human induced pluripotent stem cell (hiPSC) line of DOA patient with an OPA1 mutation. The reprogramming of this iPSC line was performed from peripheral blood mononuclear cells (PBMCs) using the non-integrative Sendai virus. The established hiPSC line retained the...

Read the complete abstract on PubMed

Topics

Cell Differentiation
Cellular Reprogramming
GTP Phosphohydrolases
Humans
Induced Pluripotent Stem Cells
Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Optic Atrophy, Autosomal Dominant

Source

Identifiers

PMID: 35152176
DOI: 10.1016/j.scr.2022.102705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Generation of a human induced pluripotent stem cell line PUMCHi019-A from a dominant optic atrophy patient with an OPA1 mutation.PMID 35152176Read ↗

Generation of an induced pluripotent stem cell line BIOi002-A from a patient with autosomal dominant optic atrophy.Semantic proximity Read ↗

Generation of a human iPSC line from a patient with an optic atrophy 'plus' phenotype due to a mutation in the OPA1 gene.Semantic proximity Read ↗

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