Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn's Disease.

Cells - 29 May 2021

Alula Kibrom M, Jackson Dakota N, Smith Andrew D, Kim Daniel S, Turner Kevin, Odstrcil Elizabeth, Kaipparettu Benny A, Dassopoulos Themistocles, Venuprasad K, Feagins Linda A, Theiss Arianne L

Abstract excerpt

Paneth cell defects in Crohn's disease (CD) patients (called the Type I phenotype) are associated with worse clinical outcomes. Recent studies have implicated mitochondrial dysfunction in Paneth cells as a mediator of ileitis in mice. We hypothesized that CD Paneth cells exhibit impaired mitochondrial health and that mitochondrial-targeted therapeutics may provide a novel strategy for ileal CD. Terminal ileal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Enterocytes

Share to Epithelium

Share to Inflammation

Share to Lipid Metabolism

Share to Paneth Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 34072441
DOI: 10.3390/cells10061349
PMCID: PMC8226558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn's Disease.PMID 34072441Read ↗

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitisSemantic proximity Read ↗

Mitochondrial dysfunction in Crohn’s diseaseSemantic proximity Read ↗

Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in miceSemantic proximity Read ↗

Emerging role of mitochondrial DAMPs, aberrant mitochondrial dynamics and anomalous mitophagy in gut mucosal pathogenesisSemantic proximity Read ↗

Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal InflammationSemantic proximity Read ↗

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicalsSemantic proximity Read ↗

The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal CancerSemantic proximity Read ↗

The Role of Ferroptosis in Inflammatory Bowel Disease: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Mitochondrial dysfunction in inflammatory bowel diseaseSemantic proximity Read ↗

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated ImmunopathologySemantic proximity Read ↗

Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironmentSemantic proximity Read ↗

TL1A overexpression in Crohn’s Disease and mice alters Paneth cells and microbiota promoting ileal inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.