Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis

28 Feb 2020

Abstract excerpt

Objective Although perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn’s disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the pathophysiology of inflammatory bowel diseases (IBD) is not well elucidated. Prohibitin 1 (PHB1), a major component protein of the inner mitochondrial membrane crucial for optimal respiratory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GDF15 and Related Biomarkers
Share to Inflammatory Bowel Disease
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32111635
DOI: 10.1136/gutjnl-2019-319523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitisPMID 32111635Read ↗

Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in miceSemantic proximity Read ↗

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn's Disease.Semantic proximity Read ↗

Paneth cells and innate mucosal immunitySemantic proximity Read ↗

Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal InflammationSemantic proximity Read ↗

Mitochondrial dysfunction in inflammatory bowel diseaseSemantic proximity Read ↗

Reduced intestinal GLP-1 <sup>+</sup> cell numbers are associated with an inflammation-related epithelial metabolic signatureSemantic proximity Read ↗

The Role of Mitochondria Dysfunction in Inflammatory Bowel Diseases and Colorectal CancerSemantic proximity Read ↗

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicalsSemantic proximity Read ↗

β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 transcription to drive parkin-dependent mitophagy in colitisSemantic proximity Read ↗

Mitochondrial dysfunction in Crohn’s diseaseSemantic proximity Read ↗

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated ImmunopathologySemantic proximity Read ↗

Emerging role of mitochondrial DAMPs, aberrant mitochondrial dynamics and anomalous mitophagy in gut mucosal pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.