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Quantification of HER family dimers by proximity ligation assay and its clinical evaluation in non-small cell lung cancer patients treated with osimertinib.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2021

Liu Renpeng, Ota Keiichi, Iwama Eiji, Yoneshima Yasuto, Tanaka Kentaro, Inoue Hiroyuki, Tagawa Tetsuzo, Oda Yoshinao, Mori Masaki, Nakanishi Yoichi, Okamoto Isamu

Abstract excerpt

OBJECTIVES: The epidermal growth factor receptor (EGFR, also known as Her1) is a member of the human epidermal growth factor receptor (HER) family of proteins and a target of tyrosine kinase inhibitors (TKIs) in the treatment of non-small cell lung cancer (NSCLC) positive for activating mutations ofEGFR. Signal transduction by HER family proteins is dependent on their homo- or heterodimerization, but little is...

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PMID: 34059353
DOI: 10.1016/j.lungcan.2021.05.023

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