Article
Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.
Internal medicine (Tokyo, Japan) - 1 Dec 2021
Murakami Ken, Yamaguchi Yuuta, Kida Yuko, Morikawa Yoichiro, Ujiie Hidetoshi, Sugahara Hiroyuki, Nannya Yasuhito, Ogawa Seishi, Kanakura Yuzuru
Abstract excerpt
Congenital mutations of the Wilms' tumor 1 (WT1) gene can lead to various abnormalities, including renal/gonadal developmental disorders and cardiac malformations. Although there have been many reports of somatic WT1 mutations in patients with acute myeloid leukemia and myelodysplastic syndrome, congenital WT1 mutations have not been reported in hematological disorders. We herein report a patient with early-onset...
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