DNMT3Aovergrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults

Abstract excerpt

DNMT3A overgrowth syndrome (DOS, also known as Tatton-Brown-Rahman Syndrome [TBRS]) is an overgrowth syndrome caused by de novo germline mutations in the gene encoding the de novo DNA-methyltransferase 3A (DNMT3A). 2] Although somatic mutations in DNMT3A are among the most common initiating events for patients with normal karyotype acute myeloid leukemia (AML) and clonal hematopoiesis, 5-9 mutations of DNMT3A are...

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