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Article

Pharmacophore anchor models of ATAT1 to discover potential inhibitors and lead optimization.

Computational biology and chemistry - 1 Aug 2021

Hsu Nung-Yu, Pathak Nikhil, Chen Yun-Ti, Hsu Yen-Chao, Yang Jinn-Moon

Abstract excerpt

Post-translation modification of microtubules is associated with many diseases like cancer. Alpha Tubulin Acetyltransferase 1 (ATAT1) is a major enzyme that acetylates 'Lys-40' in alpha-tubulin on the luminal side of microtubules and is a drug target that lacks inhibitors. Here, we developed pharmacophore anchor models of ATAT1 which were constructed statistically using thousands of docked compounds, for drug...

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Identifiers

PMID: 34052673
DOI: 10.1016/j.compbiolchem.2021.107513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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