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Article

DeepFun: a deep learning sequence-based model to decipher non-coding variant effect in a tissue- and cell type-specific manner.

Nucleic acids research - 2 Jul 2021

Pei Guangsheng, Hu Ruifeng, Jia Peilin, Zhao Zhongming

Abstract excerpt

More than 90% of the genetic variants identified from genome-wide association studies (GWAS) are located in non-coding regions of the human genome. Here, we present a user-friendly web server, DeepFun (https://bioinfo.uth.edu/deepfun/), to assess the functional activity of non-coding genetic variants. This new server is built on a convolutional neural network (CNN) framework that has been extensively evaluated....

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Identifiers

PMID: 34048560
DOI: 10.1093/nar/gkab429
PMCID: PMC8262726

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