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Article

Sjögren's syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development.

International immunology - 23 Jul 2021

Shimoyama Shuhei, Nakagawa Ikuma, Jiang Jing-Jing, Matsumoto Isao, Chiorini John A, Hasegawa Yoshinori, Ohara Osamu, Hasebe Rie, Ota Mitsutoshi, Uchida Mona, Kamimura Daisuke, Hojyo Shintaro, Tanaka Yuki, Atsumi Tatsuya, Murakami Masaaki

Abstract excerpt

Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Although many genome-wide association studies have revealed disease-associated risk alleles, the functions of the majority of these alleles are unclear. Here, we show previously unrecognized roles of GTF2I molecules by using two SS-associated single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34036345
DOI: 10.1093/intimm/dxab025
PMCID: PMC8299718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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