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Article

Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A.

Scientific reports - 20 May 2021

Reisenauer Keighley N, Tao Yongfeng, Das Provas, Song Shuxuan, Svatek Haleigh, Patel Saawan D, Mikhail Sheridan, Ingros Alec, Sheesley Peter, Masi Marco, Boari Angela, Evidente Antonio, Kornienko Alexander, Romo Daniel, Taube Joseph

Abstract excerpt

The epithelial-mesenchymal transition (EMT) imparts properties of cancer stem-like cells, including resistance to frequently used chemotherapies, necessitating the identification of molecules that induce cell death specifically in stem-like cells with EMT properties. Herein, we demonstrate that breast cancer cells enriched for EMT features are more sensitive to cytotoxicity induced by ophiobolin A (OpA), a...

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Identifiers

PMID: 34017048
DOI: 10.1038/s41598-021-89923-9
PMCID: PMC8137940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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