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Mdivi-1 induces spindle abnormalities and augments taxol cytotoxicity in MDA-MB-231 cells

20 May 2021

Abstract excerpt

Taxol is a first-line chemotherapeutic for numerous cancers, including the highly refractory triple-negative breast cancer (TNBC). However, it is often associated with toxic side effects and chemoresistance in breast cancer patients, which greatly limits the clinical utility of the drug. Hence, compounds that act in concert with taxol to promote cytotoxicity may be useful to improve the efficacy of taxol-based...

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PMID: 34016960
DOI: 10.1038/s41420-021-00495-z

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