Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.

doi:10.1007/s00401-021-02328-w

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Article

Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors.

Acta neuropathologica - 1 Aug 2021

Pathak Rajiv, Zin Francesca, Thomas Christian, Bens Susanne, Gayden Tenzin, Karamchandani Jason, Dudley Roy W, Nemes Karolina, Johann Pascal D, Oyen Florian, Kordes Uwe, Jabado Nada, Siebert Reiner, Paulus Werner, Kool Marcel, Frühwald Michael C, Albrecht Steffen, Kalpana Ganjam V, Hasselblatt Martin

Abstract excerpt

Loss of nuclear SMARCB1 (INI1/hSNF5/BAF47) protein expression due to biallelic mutations of the SMARCB1 tumor suppressor gene is a hallmark of atypical teratoid/rhabdoid tumors (ATRT), but the presence of cytoplasmic SMARCB1 protein in these tumors has not yet been described. In a series of 102 primary ATRT, distinct cytoplasmic SMARCB1 staining on immunohistochemistry was encountered in 19 cases (19%) and was...

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PMID: 34003336
DOI: 10.1007/s00401-021-02328-w
PMCID: PMC8270878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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