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Article

Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs.

eLife - 18 May 2021

Tumpara Srinu, Ballmaier Matthias, Wrenger Sabine, König Mandy, Lehmann Matthias, Lichtinghagen Ralf, Martinez-Delgado Beatriz, Korenbaum Elena, DeLuca David, Jedicke Nils, Welte Tobias, Fromme Malin, Strnad Pavel, Stolk Jan, Janciauskiene Sabina

Abstract excerpt

Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue homeostasis under physiological and pathological conditions. The factors implicated in the regulation of CX3CR1 and its specific ligand CX3CL1 (fractalkine) expression remain largely unknown. Recent studies provide evidence that host's misfolded proteins occurring in the forms of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34002692
DOI: 10.7554/eLife.64881
PMCID: PMC8205483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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