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Association between circulating alpha-1 antitrypsin polymers and lung and liver disease

15 Sept 2021

Abstract excerpt

BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is considered one of the most common genetic diseases and is characterised by the misfolding and polymerisation of the alpha-1 antitrypsin (AAT) protein within hepatocytes. The relevance of circulating polymers (CP) of AAT in the pathogenesis of lung and liver disease is not completely understood. Therefore, the main objective of our study was to determine whether...

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PMID: 34526035
DOI: 10.1186/s12931-021-01842-5

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