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Article

Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation

17 May 2021

Abstract excerpt

Several psychiatric, neurologic and neurodegenerative disorders present increased brain ventricles volume, being hydrocephalus the disease with the major manifestation of ventriculomegaly caused by the accumulation of high amounts of cerebrospinal fluid (CSF). The molecules and pathomechanisms underlying cerebral ventricular enlargement are widely unknown. Kinase D interacting substrate of 220 kDa (KIDINS220)...

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Share to Cerebrospinal fluid and hydrocephalus
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PMID: 34002021
DOI: 10.1038/s41380-021-01127-9

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