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SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis

17 May 2021

Abstract excerpt

Abstract Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O 2 − ) levels with increased accumulation of hydrogen peroxide (H 2 O 2 ) in CLL cells vs. normal B-cells. Further analysis indicated that mitochondrial superoxide dismutase (SOD)2, which converts O 2 − into H 2 O 2 remained deacetylated in CLL...

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PMID: 34001853
DOI: 10.1038/s41408-021-00484-6

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