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Article

Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate.

Journal of dental research - 1 Oct 2017

Parada-Sanchez M T, Chu E Y, Cox L L, Undurty S S, Standley J M, Murray J C, Cox T C

Abstract excerpt

Mutations and common polymorphisms in interferon regulatory factor 6 ( IRF6) are associated with both syndromic and nonsyndromic forms of cleft lip/palate (CLP). To date, much of the focus on this transcription factor has been on identifying its direct targets and the gene regulatory network in which it operates. Notably, however, IRF6 is found predominantly in the cytoplasm, with its import into the nucleus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28767310
DOI: 10.1177/0022034517723615
PMCID: PMC5613882

Genes

NME1
NME2
GRHL3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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