Article
Elucidation of the molecular mechanism of heat shock proteins and its correlation with K722Q mutations in Lon protease.
Bio Systems - 1 Sept 2017
Bhattacharjee Sanchari, Dasgupta Rakhi, Bagchi Angshuman
Abstract excerpt
Cells withstand the effects of temperature change with the help of small heat shock proteins IbpA and IbpB. The IbpAB protein complex interacts with Lon protease in their free form and gets degraded at physiological temperature when there is no temperature stress. However, the proteolytic degradation of IbpAB is diminished when Lon is mutated. The mutation K722Q in Lon brings about some structural changes so that...
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