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Article

A human infertility-associated KASH5 variant promotes mitochondrial localization.

Scientific reports - 12 May 2021

Bentebbal Sana A, Meqbel Bakhita R, Salter Anna, Allan Victoria, Burke Brian, Horn Henning F

Abstract excerpt

KASH5 is the most recently identified member of the KASH domain family of tail anchored, outer nuclear membrane (ONM) and endoplasmic reticulum (ER) proteins. During meiosis prophase I, KASH5 and SUN1 form a complex that spans the nuclear envelope and which links the telomeres of meiotic chromosomes to cytoplasmic dynein. This connection is essential for homologous chromosome dynamics and pairing. A recent study...

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Identifiers

PMID: 33980926
DOI: 10.1038/s41598-021-89439-2
PMCID: PMC8115505

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