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Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma

21 Jul 2025

Abstract excerpt

Esophageal squamous-cell carcinoma (ESCC) is one of the most common gastrointestinal cancers in China, characterized by high malignancy and poor prognosis. Nowadays, the therapeutic options for this cancer are very limited. Notch-signaling is often overactivated in ESCC, but its role remains to be fully elucidated. Here, we demonstrate that aberrant Notch-signaling plays an important role in tumor angiogenesis....

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PMID: 40691441
DOI: 10.1038/s41392-025-02309-5

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