Article
Erf Affects Commitment and Differentiation of Osteoprogenitor Cells in Cranial Sutures via the Retinoic Acid Pathway.
Molecular and cellular biology - 23 Jul 2021
Vogiatzi Angeliki, Baltsavia Ismini, Dialynas Emmanuel, Theodorou Vasiliki, Zhou Yan, Deligianni Elena, Iliopoulos Ioannis, Wilkie Andrew O M, Twigg Stephen R F, Mavrothalassitis George
Abstract excerpt
ETS2 repressor factor (ERF) haploinsufficiency causes late-onset craniosynostosis (CRS) (OMIM entry 600775; CRS4) in humans, while in mice Erf insufficiency also leads to a similar multisuture synostosis phenotype preceded by mildly reduced calvarium ossification. However, neither the cell types affected nor the effects per se have been identified so far. Here, we establish an ex vivo system for the expansion of...
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