Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats.

Environmental health perspectives - 1 May 2021

Patten Kelley T, Valenzuela Anthony E, Wallis Christopher, Berg Elizabeth L, Silverman Jill L, Bein Keith J, Wexler Anthony S, Lein Pamela J

Abstract excerpt

BACKGROUND: Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer's disease (AD). Preclinical data corroborating this association are largely from studies of male animals exposed acutely or subchronically to high levels of isolated fractions of TRAP. What remains unclear is whether chronic exposure to ambient TRAP modifies AD risk and the influence of sex on this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Air Pollution
Share to Air Quality and Health Impacts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Alzheimer's disease research and treatments

Share to Genetic Predisposition to Disease

Share to Heavy Metal Exposure and Toxicity

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 33971107
DOI: 10.1289/EHP8905
PMCID: PMC8110309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats.PMID 33971107Read ↗

Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer’s diseaseSemantic proximity Read ↗

The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk.Semantic proximity Read ↗

Exposure to environmental airborne particulate matter caused wide-ranged transcriptional changes and accelerated Alzheimer's-related pathology: A mouse studySemantic proximity Read ↗

Pro-resolving Lipid Mediators Within Brain Esterified Lipid Pools are Reduced in Female Rats Chronically Exposed to Traffic-Related Air Pollution or Genetically Susceptible to Alzheimer’s Disease PhenotypeSemantic proximity Read ↗

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer’s disease by chemically distinct air pollutantsSemantic proximity Read ↗

Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohortSemantic proximity Read ↗

Air pollution and Alzheimer disease phenotype deplete esterified proresolving lipid mediator reserves in the brain.Semantic proximity Read ↗

The Trojan Horse Effect: An Interdisciplinary Review and Recapitulation Model of the Correlation between Alzheimer’s Disease and Air Pollution Based on Neurobiology, Sociology of Medicine, and Eco-political ScienceSemantic proximity Read ↗

Short-Term Exposure to Polystyrene Microplastics Alters Cognition, Immune, and Metabolic Markers in an APOE Genotype and Sex-Dependent MannerSemantic proximity Read ↗

Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.Semantic proximity Read ↗

Association of PM2.5 Exposure and Alzheimer Disease Pathology in Brain Bank Donors-Effect Modification by APOE Genotype.Semantic proximity Read ↗

Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.