Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Air pollution and Alzheimer disease phenotype deplete esterified proresolving lipid mediator reserves in the brain.

JCI insight - 8 Aug 2025

Taha Ameer Y, Shen Qing, Otoki Yurika, Liang Nuanyi, Patten Kelley T, Valenzuela Anthony E, Wallis Christopher D, Rowland Douglas J, Chaudhari Abhijit J, Bein Keith J, Wexler Anthony S, Jin Lee-Way, Dugger Brittany N, Harvey Danielle J, Lein Pamela J

Abstract excerpt

BACKGROUNDTraffic-related air pollution (TRAP) is a risk factor for Alzheimer disease (AD), where unresolved brain inflammation has been linked to deficits in the levels of free lipid mediators that enable the resolution of inflammation. It is unknown whether these deficits are due to reductions in esterified lipid pools, the main source of free bioactive proresolving lipids in the brain, and whether they are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Air Pollution
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Lipid Metabolism

Share to Prefrontal Cortex

Share to Rats, Inbred F344

Source

Open in PubMed Open full text

Identifiers

PMID: 40359012
DOI: 10.1172/jci.insight.175917
PMCID: PMC12348674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Air pollution and Alzheimer disease phenotype deplete esterified proresolving lipid mediator reserves in the brain.PMID 40359012Read ↗

Pro-resolving Lipid Mediators Within Brain Esterified Lipid Pools are Reduced in Female Rats Chronically Exposed to Traffic-Related Air Pollution or Genetically Susceptible to Alzheimer’s Disease PhenotypeSemantic proximity Read ↗

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis.Semantic proximity Read ↗

Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer’s disease by chemically distinct air pollutantsSemantic proximity Read ↗

The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer's Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats.Semantic proximity Read ↗

The proteostatic effects of traffic-derived air pollution on Alzheimer's disease risk.Semantic proximity Read ↗

Differential Lipid Mediator Involvement in the Different Forms of Genetic Frontotemporal Dementia: Novel Insights into Neuroinflammation.Semantic proximity Read ↗

Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.Semantic proximity Read ↗

CD4+ T Cell Activation and Peripheral Immune Cell Influx into the Brain Following Wildfire Smoke Exposure is Modulated by a Saturated Fat DietSemantic proximity Read ↗

The Trojan Horse Effect: An Interdisciplinary Review and Recapitulation Model of the Correlation between Alzheimer’s Disease and Air Pollution Based on Neurobiology, Sociology of Medicine, and Eco-political ScienceSemantic proximity Read ↗

Subacute Inhalation of Ultrafine Particulate Matter Triggers Inflammation Without Altering Amyloid Beta Load in 5xFAD miceSemantic proximity Read ↗

Sex-specific neuroinflammatory responses to air pollution mediates cognitive performance in cognitively unimpaired individuals at risk of Alzheimer’s dementiaSemantic proximity Read ↗

Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.