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Article

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.

The Journal of biological chemistry - 1 Jan 2000

Carlos Anthony J, Ha Dat P, Yeh Da-Wei, Van Krieken Richard, Tseng Chun-Chih, Zhang Pu, Gill Parkash, Machida Keigo, Lee Amy S

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 (ACE2) for viral entry. However, other host factors might also play important roles in SARS-CoV-2 infection, providing new directions for antiviral treatments. GRP78 is a stress-inducible chaperone important for entry and infectivity for...

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Share to Angiotensin-Converting Enzyme 2
Share to Endoplasmic Reticulum Chaperone BiP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33965375
DOI: 10.1016/j.jbc.2021.100759
PMCID: PMC8102082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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