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Article

Patient-specific iPSC-derived cardiomyocytes reveal abnormal regulation of FGF16 in a familial atrial septal defect.

Cardiovascular research - 21 Feb 2022

Ye Lingqun, Yu You, Zhao Zhen-Ao, Zhao Dandan, Ni Xuan, Wang Yong, Fang Xing, Yu Miao, Wang Yongming, Tang Jun-Ming, Chen Ying, Shen Zhenya, Lei Wei, Hu Shijun

Abstract excerpt

AIMS: Congenital heart disease (CHD) frequently occurs in newborns due to abnormal formation of the heart or major blood vessels. Mutations in the GATA4 gene, which encodes GATA binding protein 4, are responsible for atrial septal defect (ASD), a common CHD. This study aims to gain insights into the molecular mechanisms of CHD using human-induced pluripotent stem cells (iPSCs) from a family cohort with ASD....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33956078
DOI: 10.1093/cvr/cvab154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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