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Article

Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease

9 Dec 2009

Abstract excerpt

BACKGROUND: Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection and graft-versus-host disease (GVHD) are additional barriers to its success. We performed nonmyeloablative stem-cell transplantation in adults with sickle cell disease. METHODS: Ten adults (age range, 16 to 45 years) with severe...

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Identifiers

PMID: 20007560
DOI: 10.1056/nejmoa0904971

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