Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes.

doi:10.1158/1078-0432.CCR-21-0423

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Comprehensive Molecular and Clinicopathologic Analysis of 200 Pulmonary Invasive Mucinous Adenocarcinomas Identifies Distinct Characteristics of Molecular Subtypes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2021

Chang Jason C, Offin Michael, Falcon Christina, Brown David, Houck-Loomis Brian R, Meng Fanli, Rudneva Vasilisa A, Won Helen H, Amir Sharon, Montecalvo Joseph, Desmeules Patrice, Kadota Kyuichi, Adusumilli Prasad S, Rusch Valerie W, Teed Sarah, Sabari Joshua K, Benayed Ryma, Nafa Khedoudja, Borsu Laetitia, Li Bob T, Schram Alison M, Arcila Maria E, Travis William D, Ladanyi Marc, Drilon Alexander, Rekhtman Natasha

Abstract excerpt

PURPOSE: Invasive mucinous adenocarcinoma (IMA) is a unique subtype of lung adenocarcinoma, characterized genomically by frequent KRAS mutations or specific gene fusions, most commonly involving NRG1. Comprehensive analysis of a large series of IMAs using broad DNA- and RNA-sequencing methods is still lacking, and it remains unclear whether molecular subtypes of IMA differ clinicopathologically. EXPERIMENTAL...

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PMID: 33947695
DOI: 10.1158/1078-0432.CCR-21-0423
PMCID: PMC8282731

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