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Article

Epigenetic alterations and genetic variations of angiotensin-converting enzyme 2 (ACE2) as a functional receptor for SARS-CoV-2: potential clinical implications.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Aug 2021

Kianmehr Anvarsadat, Faraoni Isabella, Kucuk Omer, Mahrooz Abdolkarim

Abstract excerpt

Receptor recognition is a crucial step in viral infection and is a critical factor for cell entry and tissue tropism. In several recent studies, angiotensin-converting enzyme 2 (ACE2) has been demonstrated to be the cellular receptor of SARS-CoV-2 as it was previously well known as the receptor of SARS-CoV. SARS-CoV-2 can bind with high affinity to human ACE2 and engages it as an entry receptor. It seems that the...

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Identifiers

PMID: 33939044
DOI: 10.1007/s10096-021-04264-9
PMCID: PMC8091148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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