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Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways

15 Jun 2022

Abstract excerpt

The angiotensin-converting enzyme 2 (ACE2) protein is a key catalytic regulator of the renin-angiotensin system (RAS), involved in fluid homeostasis and blood pressure modulation. ACE2 also serves as a cell-surface receptor for some coronaviruses such as SARS-CoV and SARS-CoV-2 . Improved characterization of ACE2 regulation may help us understand the effects of pre-existing conditions on COVID-19 incidence, as...

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PMID: 35756893
DOI: 10.1016/j.isci.2022.104614

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