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Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility

27 Aug 2022

Abstract excerpt

BACKGROUND: The ACE2 protein acts as a gateway for SARS-CoV-2 in the host cell, playing an essential role in susceptibility to infection by this virus. Genetics and epigenetic mechanisms related to the ACE2 gene are associated with changes in its expression and, therefore, linked to increased susceptibility to infection. Although some variables such as sex, age, and obesity have been described as risk factors for...

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PMID: 36038007
DOI: 10.1016/j.meegid.2022.105357

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