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From oncogenesis to prognosis: the roles of the immunoproteasome in cancer

8 Jul 2025

Abstract excerpt

The proteasome (prosome, macropain) is a key cellular organelle responsible primarily for protein homeostasis, by degrading damaged or misfolded proteins. Proteasome-processed protein fragments can then be further trimmed and funneled to the major histocompatibility complex class I (MHC-I) antigen presentation pathway for cell surface display and immune recognition. Various types of proteasomes can be found in...

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PMID: 40698074
DOI: 10.3389/fimmu.2025.1603816

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