Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Network Medicine Approach for Drug Repurposing in Duchenne Muscular Dystrophy.

Genes - 9 Apr 2021

Lombardo Salvo Danilo, Basile Maria Sofia, Ciurleo Rosella, Bramanti Alessia, Arcidiacono Antonio, Mangano Katia, Bramanti Placido, Nicoletti Ferdinando, Fagone Paolo

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a progressive hereditary muscular disease caused by a lack of dystrophin, leading to membrane instability, cell damage, and inflammatory response. However, gene-editing alone is not enough to restore the healthy phenotype and additional treatments are required. In the present study, we have first conducted a meta-analysis of three microarray datasets, GSE38417, GSE3307, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Repositioning
Share to Dystrophin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Gene Regulatory Networks

Share to Microarray Analysis

Share to Muscular Dystrophy, Duchenne

Share to Pharmacogenetics

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 33918694
DOI: 10.3390/genes12040543
PMCID: PMC8069953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Network Medicine Approach for Drug Repurposing in Duchenne Muscular Dystrophy.PMID 33918694Read ↗

Disease networks and their contribution to disease understanding and drug repurposing: Evolution of the concept, techniques and data sourcesSemantic proximity Read ↗

Exploring novel natural compound-based therapies for Duchenne muscular dystrophy management: insights from network pharmacology, QSAR modeling, molecular dynamics, and free energy calculationsSemantic proximity Read ↗

DomainScope: A disease network based on protein domain connectionsSemantic proximity Read ↗

Systematic Evaluation of Molecular Networks for Discovery of Disease Genes.Semantic proximity Read ↗

Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophySemantic proximity Read ↗

Drug Repurposing Through a Bioinformatics Pipeline Applied on Fibrotic DiseasesSemantic proximity Read ↗

An approach to infer putative disease-specific mechanisms using neighboring gene networks.Semantic proximity Read ↗

A network medicine framework for multi-modal data integration in therapeutic target discoverySemantic proximity Read ↗

A network-based model for drug repurposing in Rheumatoid ArthritisSemantic proximity Read ↗

5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene ExpressionSemantic proximity Read ↗

GRAND: A database of gene regulatory network models across human conditionsSemantic proximity Read ↗

A 5-repurposed drug candidates identified in motor neurons and muscle tissues with amyotrophic lateral sclerosis by network biology and machine learning based on gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.