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BRCA1/2 Mutation Detection in the Tumor Tissue from Selected Polish Patients with Breast Cancer Using Next Generation Sequencing.

Genes - 2 Apr 2021

Szczerba Ewelina, Kamińska Katarzyna, Mierzwa Tomasz, Misiek Marcin, Kowalewski Janusz, Lewandowska Marzena Anna

Abstract excerpt

(1) Background: Although, in the mutated BRCA detected in the Polish population of patients with breast cancer, there is a large percentage of recurrent pathogenic variants, an increasing need for the assessment of rare BRCA1/2 variants using NGS can be observed. (2) Methods: We studied 75 selected patients with breast cancer (negative for the presence of 5 mutations tested in the Polish population in the...

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Identifiers

PMID: 33918338
DOI: 10.3390/genes12040519
PMCID: PMC8065856

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