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Article

Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells.

International journal of molecular sciences - 1 Apr 2021

Degli Esposti Chiara, Iadarola Barbara, Maestri Simone, Beltrami Cristina, Lavezzari Denise, Morini Martina, De Marco Patrizia, Erminio Giovanni, Garaventa Alberto, Zara Federico, Delledonne Massimo, Ognibene Marzia, Pezzolo Annalisa

Abstract excerpt

Neuroblastoma (NB) is an aggressive infancy tumor, leading cause of death among preschool age diseases. Here we focused on characterization of exosomal DNA (exo-DNA) isolated from plasma cell-derived exosomes of neuroblastoma patients, and its potential use for detection of somatic mutations present in the parental tumor cells. Exosomes are small extracellular membrane vesicles secreted by most cells, playing an...

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Identifiers

PMID: 33915956
DOI: 10.3390/ijms22073667
PMCID: PMC8036333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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