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Characteristics and Clinical Application of Extracellular Vesicle-Derived DNA

29 Jul 2021

Abstract excerpt

Extracellular vesicles (EVs) carry RNA, proteins, lipids, and diverse biomolecules for intercellular communication. Recent studies have reported that EVs contain double-stranded DNA (dsDNA) and oncogenic mutant DNA. The advantage of EV-derived DNA (EV DNA) over cell-free DNA (cfDNA) is the stability achieved through the encapsulation in the lipid bilayer of EVs, which protects EV DNA from degradation by external...

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PMID: 34359729
DOI: 10.3390/cancers13153827

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