Article
Lunatic fringe promotes the aggregation of CADASIL NOTCH3 mutant proteins.
Biochemical and biophysical research communications - 11 Jun 2021
Suzuki Shodai, Hiura Satoshi, Mashiko Taiki, Matsumoto Takemi, Itoh Motoyuki
Abstract excerpt
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic small vessel disease characterized by NOTCH3 mutation and abnormal aggregation of NOTCH3 mutant proteins around vessel walls. NOTCH3 is a transmembrane receptor that is degraded by JAGGED1 (JAG1) through a process called trans-endocytosis. There are two types of CADASIL-associated NOTCH3 mutations:...
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