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Article

Adherens junction engagement regulates functional patterning of the cardiac pacemaker cell lineage.

Developmental cell - 17 May 2021

Thomas Kandace, Henley Trevor, Rossi Simone, Costello M Joseph, Polacheck William, Griffith Boyce E, Bressan Michael

Abstract excerpt

Cardiac pacemaker cells (CPCs) rhythmically initiate the electrical impulses that drive heart contraction. CPCs display the highest rate of spontaneous depolarization in the heart despite being subjected to inhibitory electrochemical conditions that should theoretically suppress their activity. While several models have been proposed to explain this apparent paradox, the actual molecular mechanisms that allow...

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Identifiers

PMID: 33891897
DOI: 10.1016/j.devcel.2021.04.004
PMCID: PMC8137639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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