Article
Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank.
Human molecular genetics - 9 Jul 2021
De Lillo Antonella, D'Antona Salvatore, Pathak Gita A, Wendt Frank R, De Angelis Flavio, Fuciarelli Maria, Polimanti Renato
Abstract excerpt
To investigate cross-ancestry genetics of complex traits, we conducted a phenome-wide analysis of loci with heterogeneous effects across African, Admixed-American, Central/South Asian, East Asian, European and Middle Eastern participants of the UK Biobank (N = 441 331). Testing 843 phenotypes, we identified 82 independent genomic regions mapping variants showing genome-wide significant (GWS) associations...
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