Article
NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target.
mBio - 20 Apr 2021
Fenn Samuel, Dubern Jean-Frédéric, Cigana Cristina, De Simone Maura, Lazenby James, Juhas Mario, Schwager Stephan, Bianconi Irene, Döring Gerd, Elmsley Jonas, Eberl Leo, Williams Paul, Bragonzi Alessandra, Cámara Miguel
Abstract excerpt
The opportunistic pathogen Pseudomonas aeruginosa produces an arsenal of virulence factors causing a wide range of diseases in multiple hosts and is difficult to eradicate due to its intrinsic resistance to antibiotics. With the antibacterial pipeline drying up, antivirulence therapy has become an attractive alternative strategy to the traditional use of antibiotics to treat P. aeruginosa infections. To identify...
Topics
- Ammonia
- Animals
- Bacterial Proteins
- Caenorhabditis elegans
- Cell Line
- Disease Models, Animal
- Drosophila melanogaster
- Ferredoxins
- Gene Library
- Humans