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Article

Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa.

Infection and immunity - 1 Oct 2009

Van Alst Nadine E, Wellington Melanie, Clark Virginia L, Haidaris Constantine G, Iglewski Barbara H

Abstract excerpt

The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants to evaluate the virulence of P. aeruginosa PA14 in a model of P. aeruginosa-phagocyte...

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Identifiers

PMID: 19651860
DOI: 10.1128/IAI.00822-09
PMCID: PMC2747934

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