Article
Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa.
Infection and immunity - 1 Oct 2009
Van Alst Nadine E, Wellington Melanie, Clark Virginia L, Haidaris Constantine G, Iglewski Barbara H
Abstract excerpt
The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimi...
Topics
- Animals
- Bacterial Proteins
- Cell Line
- Cell Survival
- Colony Count, Microbial
- Gene Deletion
- Gene Knockout Techniques
- Humans
- Membrane Transport Proteins
- Microbial Viability
- Monocytes
- Mutation
- Nitrate Reductase
- Nitrite Reductases
- Pseudomonas aeruginosa