Article
RNA kinase CLP1/Cbc regulates meiosis initiation in spermatogenesis.
Human molecular genetics - 12 Aug 2021
Wu Jianbo, Li Xin, Gao Zhiyang, Pang Lin, Liu Xian, Huang Xiahe, Wang Yingchun, Wang Zhaohui
Abstract excerpt
CLP1, TSEN complex, and VCP are evolutionarily conserved proteins whose mutations are associated with neurodegenerative diseases. In this study, we have found that they are also involved in germline differentiation. To optimize both quantity and quality in gametes production, germ cells expand themselves through limited mitotic cycles prior to meiosis. Stemming from our previous findings on the correlation...
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